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Nature???|??????????????????????DNA?????????????

  • ?????????
  • ?????2019-01-28
  • ?????iNature

iNature??????????????(ASFV)???д??????????????????????????ASFV DNA?????(AsfvLIG)???????????????????????????????????ASFV DNA????????е?DNA???????????????????????????????????á?

2019??1??23???????????????,????????????/?????????????Huang Zhen?????????Nature Communications ????????“Structure of the error-prone DNA ligase of African swine fever virus identifies critical activesite residues”?????£??????????????????λ??л?(AD?????Asn 153??Leu 211??OB?????Leu 402??Gln 403)??AsfvLIG????Ч???????????

????????????(ASFV)????????DNA?????????и????????????????????????????????????ASFV????????С??170??190 kb???????150????????????Щ???????????ASFV??????????????Σ???????????DNA??????????????????????????????????????????AsfvLIG??419???????????????????????С??DNA?????????AsfvLIG????????????????????(AD)????C???????OB???????(OB)??AD??OB?????????????ж????????????AD??OB?????????DNA????????????DNA?????(DBD)???????????????????????????????AsfvLIG??N??????(NTD)???????????DBD????????????????

AsfvLIG???????

AsfvLIG????????????л???????AD???Asn 153??Leu 211?????OB?????Leu 402??Gln 403??????????????????????????Щ?л??????????????NTD??DBD????Э?????????Щλ??л?????????????Ч??????????????塣

?????·????4??????????????????С???????????е?????????ASFV?????????????????????????????????

???????????????????????31870721,31470724,31670878,21572146,21761132029?????й?????з??????2016YFA0500600????????????з??????2018NZ0151???????????